Peptidia Serum

Face, neck and décolleté

The Perfect Symbiosis between Biotechnological Intelligence and the absolute Purity of Nature

Peptidia Serum unisce biotecnologia di precisione alla purezza della natura in un equilibrio perfetto. Il cuore della formula è il Tetrapeptide-21, un messaggero intelligente che stimola la produzione di collagene, acido ialuronico e fibronectina per una pelle soda e tonica. La ricetta include un complesso di 5 acidi ialuronici per un’idratazione stratificata e l’acido lattobionico che esfolia delicatamente e affina la grana cutanea. Veicolati da una base naturale di acqua di amamelide e succo di aloe vera, gli ingredienti lavorano in sinergia per donare risultati visibili: rughe attenuate, compattezza ritrovata e idratazione prolungata. La texture leggera e la composizione delicata lo rendono adatto a tutte le pelli, anche le più sensibili e reattive. Applicabile su viso, collo, décolleté e contorno occhi in un gesto di cura quotidiano che unisce efficacia, sicurezza e rispetto per pelle e ambiente.

Add to bag - €60.00
  • Advanced biotechnological action: Tetrapeptide-21 activates the skin's natural regeneration processes.
  • Layered and prolonged hydration: the complex of 5 hyaluronic acids ensures immediate and progressive hydration.
  • Visible anti-aging effect: reduces wrinkles and expression lines, restoring firmness to the skin.
  • Light, non-sticky texture: absorbs quickly without greasing.
  • Suitable for all skin types: delicate formulation, also ideal for sensitive and reactive skin.
  • Multi-zone: applicable to the face, neck, décolleté and eye contour.
  • Sustainable formula: respect for the skin and the environment, with biodegradable ingredients.

INCI

INCI – SYNERGISTIC ACTION AND PROPERTIES’ 

Hamamelis Virginiana aqua, Aloe Barbadensis Leaf juice, Tetrapeptide-21, Glycerin, Butylene Glycol, Hyaluronic acid (3kda-8kda,0,8m-1,5m,1,8m 3,0mda,100k-500k), Sodium Hyaluronate, Lactobionic acid, Parfum, Tocopheryl acetate, Potassium sorbate, Sodium benzoate, Phenoxyethanol.

NB The natural ingredients used come from organic farming.

Does not contain:

✅ SILICONES FREE: For skin that breathes and absorbs 100% of the active ingredients.

✅ WITHOUT DENATURED ALCOHOL: Suitable even for the most sensitive and reactive skin.

✅ PARABEN FREE: Safe and modern preservative system.

✅ SLS/SLES FREE: Non-aggressive formula.

✅ MINERAL OIL FREE: Natural, plant-based hydration.

✅ PHTHALATES FREE: Even in the perfume, maximum transparency.

✅ PRODUCT NOT TESTED ON ANIMALS

SAFETY AND COMPLETE COMPOSITION

Commitment to consumer safety and formula transparency are core values of Peptidia serum. This section offers a complete analysis of the INCI, providing a detailed overview of each ingredient and ensuring the absence of hazardous substances.

INCI Analysis

The ingredient list (INCI) is proof of a product's composition. Each component of Peptidia serum has been selected for its specific function and safety profile. Below is a detailed analysis.

1) Acqua (Hamamelis Virginiana aqua, Aloe Barbadensis Leaf juice): La base del siero è composta da acqua di hamamelis e succo di aloe vera, che non si limitano a essere un semplice solvente, ma apportano proprietà lenitive, idratanti e decongestionanti fin dall’inizio.

2) Attivi Biotecnologici (Tetrapeptide-21, Hyaluronic acid, Sodium Hyaluronate, Lactobionic acid): Il cuore della formula. Il Tetrapeptide-21 agisce come stimolatore biologico, mentre il complesso di acidi ialuronici a pesi molecolari multipli garantisce un’idratazione profonda e a lunga durata.

3) L’acido lattobionico completa il quadro con la sua azione idratante, antiossidante e delicatamente esfoliante.

4) Emollienti e Umettanti (Glycerin, Butylene Glycol): La glicerina e il butilene glicole sono agenti umettanti e condizionanti ampiamente utilizzati per la loro capacità di attirare e trattenere l’acqua nella pelle, migliorando ulteriormente l’idratazione e la texture del prodotto.

5) Antiossidante (Tocopheryl acetate): Un antiossidante cruciale che protegge la formula dall’ossidazione e fornisce benefici protettivi alla pelle contro i danni dei radicali liberi.

6) Sistema di Conservazione (Potassium sorbate, Sodium benzoate, Phenoxyethanol): La sicurezza e la stabilità del siero sono garantite da un sistema conservante sinergico. Questa combinazione di conservanti ad ampio spettro è riconosciuta a livello globale e considerata un’alternativa sicura e non controversa ai parabeni.

7) È efficace nel prevenire la crescita di una vasta gamma di microrganismi, inclusi batteri, lieviti e muffe, assicurando la freschezza e l’integrità del prodotto durante l’uso. La loro efficacia è massima a un pH acido, ideale per le formulazioni a base di acidi.

8) Altri Componenti (Parfum, Phenoxyethanol): Il profumo viene aggiunto in piccola quantità per rendere l’esperienza sensoriale piacevole. Il fenossietanolo è un conservante noto per la sua efficacia antibatterica. 

SYNERGISTIC ACTION AND PROPERTIES'

 
 

   Targeted Action of the Main Ingredients:

  • Tetrapeptide-21: A biomimetic "smart" peptide, this peptide is a sequence based on the structure of the skin itself. It acts as a biological signal to reactivate the production of collagen, hyaluronic acid, and fibronectin, essential elements for skin density and elasticity. Its targeted action helps minimize the appearance of all types of wrinkles and reduce skin roughness, for a visible and long-lasting anti-aging effect.
  • 5M Hyaskin™ (Hyaluronic Acid Complex): An advanced blend of five types of sodium hyaluronate with different molecular weights. It acts on every layer of the skin to ensure complete hydration: high molecular weight hyaluronic acids form a protective film that prevents superficial dehydration, while low molecular weight hyaluronic acids penetrate deeper for long-lasting, plumping hydration.
  • Lactobionic Acid: A next-generation polyhydroxy acid (PHA), known for its gentleness. It performs a very gentle exfoliating action that renews the skin without irritating it, improving the evenness of the complexion and enhancing the effectiveness of other active ingredients by facilitating their absorption.
  • Witch Hazel Water and Aloe Juice: A rich base with soothing and rebalancing properties. Witch hazel water has astringent and decongestant properties, ideal for purifying and soothing the skin, while aloe vera juice provides deep hydration and regenerating action, supporting healing and skin vitality.
  • Tocopheryl Acetate: The stable form of vitamin E, a powerful antioxidant that protects skin from free radical damage caused by environmental factors such as pollution and UV rays. It helps maintain the stability and effectiveness of the entire formula.

The Excellence of Synergy:

  • Enhanced Biological Regeneration: Tetrapeptide-21 works in perfect harmony with aloe juice to stimulate the production of key components of the extracellular matrix. This combination acts as an internal signal for repair and rejuvenation, promoting cell renewal and helping restore skin elasticity.
  • Synergy between Tetrapeptide 21 and the Complex of 5 Hyaluronic Acids: Hyaluronic acid creates a water reservoir that promotes the absorption of the peptide, which in turn stimulates the production of new endogenous hyaluronic acid and collagen. The result is a "circle of youth" effect: hydration → stimulation → repair → prolonged youthfulness.
  • Double Deep Hydration: Lactobionic Acid improves hydration and prepares the skin to receive the 5M Hyaskin™ complex. This complex provides layered hydration: the larger hyaluronic acids create a protective barrier against transepidermal water loss (TEWL), while the smaller ones penetrate deeper for internal hydration and a plumping effect.
  • Maximum Absorption and Functionality: The gently exfoliating action of Lactobionic Acid removes dead surface cells, optimizing skin permeability. This allows Tetrapeptide-21 and the hyaluronic acid complex to penetrate more effectively, reaching the layers where they can exert their maximum regenerative effect.
  • Total Protection and Soothing: The base of highly pure Hamamelis water and Aloe juice creates a soothing and decongestant environment that reduces irritation and redness, making the Peptidia serum suitable for even the most sensitive skin and ensuring an immediate sensation of freshness and comfort.

SCIENTIFIC INSIGHT: THE INGREDIENT LIBRARY

This section provides an in-depth analysis of each component of the Peptidia formula, focusing on the scientific evidence supporting its effectiveness, offering consumers a complete and transparent view of the product.

Introduction:

Each ingredient has been selected for its proven effectiveness, working in perfect harmony to give you visible and long-lasting results.

Tetrapeptide-21: The Extracellular Matrix Activator

Il Tetrapeptide-21 è un peptide biotecnologico la cui sequenza aminoacidica (GEKG) è stata identificata attraverso metodi bioinformatici, replicando una struttura presente nella matrice extracellulare (ECM) della pelle. Questo lo rende un “peptide di segnale” che attiva la risposta biologica delle cellule cutanee. La sua funzione principale è stimolare la biosintesi dei componenti fondamentali dell’ECM, come il collagene, la fibronectina e l’acido ialuronico, che sono cruciali per la forza, l’elasticità e la resistenza della pelle.

The effectiveness of this ingredient has been extensively documented through rigorous clinical studies both in vitro That in-vivo.

🔹 Origin and mechanism

Tetrapeptide-21 is a synthetic oligopeptide developed to mimic small fragments resulting from the natural degradation of the collagen I.
These fragments, when released, activate dermal fibroblasts: the peptide replicates this signal and stimulates the endogenous synthesis of the main components of the extracellular matrix (ECM):

  • Collagen I, III and VII
  • Fibronectin
  • Hyaluronic Acid

It acts mainly through the TGF-β/Smad pathway and the gene regulation of ECM factors.

🔹 Experimental evidence

  • In vitro: +250 % collagen production at 1 ppm on human fibroblasts (Sircol™ Assay).
  • In vivo: +41 % skin elasticity, −25 % surface roughness after 8 weeks.

🔹 Cosmetic benefits

  • Visibly reduces wrinkles and fine lines.
  • Improves the firmness and density of the dermis.
  • Increases skin brightness and uniformity.
  • Deep and progressive “restructuring” effect.                                         

🔹 Tolerability

Highly biocompatible, non-irritating, suitable for daily use on all skin types.

🧩 2. The main categories of cosmetic peptides

Category

Description and Mechanism

Typical examples

Main effect

1. Signal Peptides

They trigger the synthesis of collagen, elastin and HA by mimicking ECM fragments.

Palmitoyl Pentapeptide-4, Acetyl Tetrapeptide-9, Tetrapeptide-21 (GEKG)

Structural rejuvenation, increased elasticity.

2. Neurotransmitter-inhibiting peptides (Botox-like)

They block the nerve transmission of acetylcholine, relaxing the mimic muscles.

Acetyl Hexapeptide-8, Dipeptide 

Reduction of dynamic wrinkles, “botox-like” effect.

3. Carrier Peptides (transport)

They chelate and transport metal ions (copper, zinc, manganese) essential for tissue repair.

Copper Tripeptide-1 (GHK-Cu), Mn-Tripeptide-1

Healing, antioxidant, deep repair.

4. Enzyme inhibitory peptides (Anti-MMP)

They inhibit metalloproteinases (MMPs) that degrade collagen and elastin.

Tripeptide-29, Hexapeptide-12

Protection and prevention of photoaging.



3. Comparison of Tetrapeptide-21 (GEKG) with the four classes of peptides

Class

Mechanism of action

Skin benefits

Comparison with Tetrapeptide-21 (GEKG)

1. Signal Peptides

They stimulate the synthesis of ECM (collagen, elastin, HA).

Firming, filling effect, improved texture.

GEKG it is a signal peptide A new generation, more targeted at collagen I and III than Matrixyl®. It offers superior performance in terms of elasticity and density.

2. Botox-like peptides

They inhibit muscle contraction by blocking acetylcholine.

Immediate reduction of expression lines.

GEKG it does not act on the muscles, but reconstructs the dermis. More progressive yet structural and natural results.

3. Carrier Peptides

They transport metal ions to activate repair enzymes.

Regeneration and antioxidant protection.

GEKG does not transport metals, but it stimulates the internal production of hyaluronic acid and collagen. It is more stable and delicate.

4. Anti-enzyme peptides

They inhibit MMP 1 and 9 to preserve collagen and elastin.

Protection of the dermal structure and prevention of photoaging.

GEKG acts upstream: stimulates new collagen synthesis, compensating for degradation. Improved long-term restructuring effect.



5M Hyaskin™: The 5-Dimensional Hydration Complex

5M Hyaskin™ is an innovative blend of five different types of sodium hyaluronate, each with a specific molecular weight. This combination has been formulated to act on every layer of the skin, ensuring intense hydration and complete protection. The complex works on two distinct levels.1

  • Surface Action: Hyaluronic acid molecules at high and medium molecular weight They are too large to penetrate deeply. Their function is to create a thin, protective film on the skin's surface. This layer acts as a barrier, drastically reducing transepidermal hydration loss and retaining existing moisture, providing an immediate sensation of tighter, smoother skin.1
  • Deep Action: Hyaluronic acid molecules at low and very low molecular weight They have the ability to penetrate the deepest layers of the epidermis. Once absorbed, they help improve and prolong internal hydration, filling the skin's microstructure and providing a lasting and visible plumping effect.

Lactobionic Acid: The Gentle and Multifunctional Revitalizer

Lactobionic Acid is a next-generation polyhydroxy acid (PHA), appreciated for its very gentle exfoliating action, making it ideal for even the most sensitive skin, including those suffering from acne or rosacea. Unlike more aggressive alpha-hydroxy acids (AHAs), PHAs perform their functions without causing irritation. Its properties extend far beyond simple exfoliation:

  • Hydration: It possesses remarkable hygroscopic properties, meaning it attracts and retains atmospheric water. Applied to the skin, it forms a protective, moisturizing film that acts as an emollient and limits water loss.
  • Antioxidant Action: It is able to inhibit the formation of free radicals, contributing to cellular protection and the prevention of skin aging.
  • Prevention of Photoaging: Lactobionic acid has the ability to block the production of metalloproteinases (MMPs), enzymes that degrade collagen, whose activity is stimulated by UV rays and the natural aging process. This helps preserve the skin's structural integrity.
  • Cellular Renewal: It promotes gentle cell turnover and keratinization, improving the appearance of the skin and making it brighter and more even.

Hamamelis and Aloe: The Soothing and Purifying Base

The formula is enriched with a base of natural, organic ingredients, known for their soothing and rebalancing properties.

  • Hamamelis Virginiana water: Derived from the witch hazel plant, it has historically been used for its soothing, astringent and decongestant properties.3 It helps calm the skin, reduce redness and balance sebum production, making the serum suitable for all skin types.10
  • Aloe Barbadensis Juice: Extracted from the leaves of the aloe vera plant, this ingredient is a source of vitamins, minerals, and amino acids. It is renowned for its hydrating and regenerative properties, penetrating deeply to nourish and revitalize the skin. It promotes cell regeneration, helps restore the skin barrier, and provides elasticity, contributing to the formula's overall anti-aging action.

Tocopheryl Acetate: The Protective Antioxidant

Tocopheryl acetate is a synthetic, and significantly more stable, form of vitamin E.5 Its stability makes it an ideal ingredient for cosmetic formulations, as it does not degrade easily when exposed to heat, air, and light. Its function is twofold:

  1. Formula Protection: It acts as an antioxidant, preventing the oxidation of other sensitive ingredients and ensuring the longevity and effectiveness of the product over time.5

Antioxidant Action on the Skin: 

Although conversion to its active form, tocopherol, is limited in the uppermost layers of the skin, Tocopheryl Acetate still penetrates the most vital layers, where it can be partially converted and help protect cells from damage caused by free radicals and UV radiation.5 This makes it a crucial component of daily skin protection.

DIRECTIONS FOR USE

 

The use of the product is recommended both morning and evening, or both options for more mature skin.

A nourishing and protective face cream, ideal for very sensitive, dry or atopic-prone skin.

Thanks to a rich but non-occlusive formula, it helps restore skin comfort, reduce redness and dryness, and strengthen the skin's natural defenses.

It contains a minimal amount of fragrance, chosen to minimize the risk of sensitization, while maintaining a pleasant user experience. 

“To maximize the effectiveness of Peptidia serum, follow these simple steps. Proper application not only optimizes results but also transforms your treatment into a true moment of wellness.”

Detailed Instructions for Use:

Prepare the Skin:

Dopo la detersione, asciuga il viso tamponando, lasciando la pelle leggermente umida. Questo passaggio è cruciale.

Strategic Movements:

Versa 2-3 gocce di siero sul palmo della mano, scaldale delicatamente e distribuiscile su tutto il viso e il collo con movimenti lenti e decisi dal basso verso l’alto e dall’interno verso l’esterno, massaggiando circolarmente.

Targeted Action:

Picchietta delicatamente il prodotto con la punta delle dita, concentrandoti in modo particolare sulle aree in cui le rughe d’espressione sono più visibili: il contorno occhi, il contorno bocca e la zona della fronte tra le sopracciglia.

The Scientific Reason Behind Every Gesture:

Perché applicare il siero sulla pelle umida?

L’Acido Ialuronico è un umettante, una molecola che agisce come una spugna, attirando e trattenendo l’acqua. Applicandolo su pelle leggermente umida, il siero ha a disposizione l’acqua sulla superficie cutanea da legare, garantendo che non prelevi l’idratazione dagli strati più profondi della pelle, un fenomeno che potrebbe altrimenti portare a una sensazione di secchezza. Questo passaggio garantisce un effetto “plumping” immediato e superiore.

Perché picchiettare e con movimenti specifici?

I movimenti di picchiettio e il massaggio leggero favoriscono la microcircolazione sanguigna negli strati superficiali della pelle. Questo non solo aumenta la permeabilità cutanea, facilitando l’assorbimento ottimale degli ingredienti attivi come il Tetrapeptide-21 e gli acidi ialuronici, ma contribuisce anche a rivitalizzare l’incarnato. I movimenti dal basso verso l’alto e dall’interno verso l’esterno seguono le linee di tensione naturale della pelle e aiutano a massimizzare il potenziale effetto lifting e rassodante del siero, veicolando gli attivi proprio dove l’invecchiamento è più evidente.

WARNINGS: SAFETY AND COMPLETE COMPOSITION

 

The Peptide Regenerating Serum It is a concentrated treatment with high dermocompatibility, formulated for use exclusively external.
 Contains new generation natural and biotechnological active ingredients — like the Tetrapeptide-21, the’Multi-weight Hyaluronic Acid, the’Lactobionic Acid and the pure extracts of Witch hazel e Aloe Vera — selected for their effectiveness and purity.

All the ingredients are of natural origin or sustainable biotechnological derivation, carefully balanced to ensure the maximum skin tolerability even for the most sensitive skin.

 Security and Conservation

  • Do not use if: hypersensitivity or intolerance to one or more components of the formula.
  • Avoid direct contact with the ocular mucosa. In case of accidental contact, rinse with plenty of water.
  • Do not ingest.
  • Hold out of reach of children.
  • Store in place cool, dry and away from direct light and heat sources, to maintain the integrity and stability of the assets.

PAO (Period After Opening): 12 months.
 After opening, the product maintains its effectiveness and safety for 12 months, if stored properly.

Each batch is subjected to rigorous safety, stability and skin compatibility tests, in accordance with the Regulation (EC) No. 1223/2009 on cosmetic products.

 Green Formula: principles and values

In European cosmetic language, a formula can be defined as “green” o “eco-responsible” When:

  • employs renewable natural or biotechnological ingredients,
  • reduces or eliminates the use of petrochemical or persistent substances,
  • is made through sustainable production processes,
  • respect animals and biodiversity.

This serum meets these criteria, blending advanced science and natural purity.

What makes Peptide Serum a green formula?

✅ High percentage of natural and biofunctional ingredients
  • Witch hazel (Hamamelis virginiana) e Aloe Vera, waters and gels rich in polyphenols and mucopolysaccharides with soothing and antioxidant action.
  • Multi-weight Hyaluronic Acid e Sodium Hyaluronate, for deep, multi-level hydration.
  • Tetrapeptide-21, a biomimetic peptide that stimulates the production of collagen and elastin.
  • Lactobionic Acid, a delicate latest-generation polyacid that renews and smoothes without irritating.
 
✅ Absence of controversial or non-eco-friendly substances
  • No silicone, mineral oil, PEG o paraben.
  • No synthetic dye o microplastic.
  • Alone delicate fragrance, free from significant allergens.
 
✅ Safe preservatives and stabilizers
  • Phenoxyethanol, Sodium Benzoate and Potassium Sorbate: preservatives permitted in the standards ECOCERT e COSMOS, used in controlled and safe concentrations.
  • Tocopheryl Acetate (Vitamin E): natural antioxidant that preserves the stability of the formula and protects the skin from oxidative stress.

 

Controversial substances: absence and compliance

The serum is totally free of controversial substances — such as cyclic silicones, parabens, BHA/BHT, EDTA, triclosan, formaldehyde and petrochemical derivatives.
 All the ingredients are compliant with Regulation (EC) 1223/2009 and comply with the latest criteria Green Chemistry e Sustainable Beauty.

The ritual for skin that breathes purity and light.